Nope...culinarily speaking, VG is a fat....like any type of oil...so it will take the cannabinoids just like making butter or what ever. I got my mom started on the e-liquid because she doesn't like smoking. After about two weeks of daily use for her pain, she is FINALLY starting to come off of her opiod meds.I always thought u needed to homogenize or emulsify or something in order to achieve a proper bond with the vg