I start defoliating in week 2 or 3 and continue to defoliate almost daily until they’re chopped. My last grow I lollipopped 7-8 plants and topped two of those. No signs of issues with any of them. I ended up yielding 1 lb. Plus from each of 4 plants that were had the most HST, but they were the bigger plants to begin with, so hard to say how it effected yields. I will say, each of those plants had more left in them as I had to chop early due to space issues and not being able to stake or even get to some of my plants after they were in flower. Back right is an ILGM WW (you can only see half if it) that yielded nearly 650g.