I did some heavy defoliating and some of mine didn't take to well...it was doing great now has brown spots all over all the top leaves on every cola...here's some pics...I followed a thread on defoliating on here....others are doing ok. I removed 1 pound 8.9 oz of leaves and some lower branches....do what you feel is right..my opinion. Only do a little every few days...so you don't shock your plant...this is my first grow...and I did my gg#4 a little at a time and they did well....hope this helps...I'm going to follow manogreen advice with my next plants...only in late flower....I did 8 plants total... The brown spots started the next day after I defoliated my monster....lol