As I understand the concept, ideal VPD is about growth efficiency, and is all about the RH at which leaves function at their best. Too wet, and transpiration is reduced, too dry and stomata close with the same result. Just right, and stomata are fully open and maximum transpiration and photosynthesis is possible, as determined by whatever the next most limiting factor is. And as pointed out in earlier comments, VPD depends on
leaf temperature, and the RH
in your canopy.
As to leaf temps, if you use VPD charts, you will see that they are (or should be) labeled as applying to a particular leaf temperature, expressed as the number of degrees cooler than the air temperature. Transpiration is evaporation of water which cools leaves, hence the normal status of leaves being cooler than air. I use charts rather than a calculator. My chart is tacked to my growdrobe door.
The big difference under LEDs vs. HPS is that the latter emit a lot of infra red heat and tend to raise leaf temperature, but LED's emit far less, so leaf temps stay lower. If you want the best info for your grow, check leaf temps with an infrared thermometer, and calculate VPD or use the appropriate chart accordingly. If you don't have a thermometer, assuming a couple degrees cooler will likely get you in the ballpark if you are using LEDs, which quite frankly is all that is required.
As to the issue of flowering, once your buds start getting fat and dense, the importance of VPD for photosynthetic efficiency becomes out weighed by the need to avoid bud rot, and that means keeping humidity lower than VPD charts would otherwise suggest. I have limited experience, but what I do have suggests that all that is required to avoid rot is to keep VPD at the low end of the acceptable range, and make sure that you have consistent and good air circulation through the canopy. Avoiding bud rot may also require some pruning to make sure that air circulation is good, particularly in some Indica leaning strains which can stay bushy and dense as well as developing large fat colas vulnerable to rot.
So, bottom line is that the right VPD chart is your friend during vegetative growth until somewhere around mid flower, but after that, you need to reduce humidity somewhat to avoid bud rot. In effect, you are sacrificing a bit if photosynthetic efficiency to protect your precious bud in it final fattening up.
Happy growing
@Filthy_Casual.