I've been doing coco for the past decade for the most part. I've also done RDWC and Mapito, but hands down my favorite is coco. Right now going back to pure organics in preparation for outdoor growing.
Run-off is a half-myth. It is pushed by nute companies to help sell their products more. But there is good reason for their claims. Salt build-up is a real thing and a potencial problem, and regularly flushing your coco is a good thing. So run-to-waste is indeed an effective was to mitigate this problem. But it is also a LAZY way to deal with it, and typical of super large commercial setups. I've done several runs with the same coco without run-to-waste with great success.
You DO NOT need to apply run-to-waste in your indoor grows. It only wastes nutes.
If you are having deficiencies/toxicity issues, then for sure - flush the coco as best you can and reset.
Otherwise, running a few feeds with plain water, or better, AACT feeds - will 100% take care of your rhizosphere. The majority of the root mass is in the upper 1/3 to 2/3 of the pot. So the most important thing is what you top feed, not what comes out from the bottom. Plant exudates are super important to its self-regulation, so excessive "flushing" does not do you any service. at all.
Having said this - pure hydro doesn't give a damn about exudates. It force feeds the plant.
So in a nutshell, run-to-waste is a factor between your nutrient costs vs final yield ratio. It is not a recipe for better or higher yielding crops.
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