Looks exactly like a magnesium issue. Calcium is immobile.. Calcium issues start at the top and spread down the plant. Magnesium is mobile.. Issues start at the bottom/ lower middle of work their way up. The leaves have classic interveinal (occurring near or in-between veins) yellowing and rust spots, which is a sign of a magnesium issue. I tell people all the time that calcium and magnesium are two complete different nutrients that effect the plant differently, and are treated differently.
What caused it? It's hard to say. Most likely an excess of something (potassium or calcium probably) since your feeding a 17 day old plant bottled nutes and brews.. Happy frog has enough available nutrients to get an auto through the first 3 week without adding a thing exact water.. Everything you've added so far has had an effect on the balance of nutrients available.. It's not a "deficiency" if you're feeding the plant and have used cal mag.. Happy frog has an abundance of calcium already in it. Too much calcium will lock out magnesium.. So will too much potassium. These types of issues are present days, even weeks before they show signs on the leaves. Some plants can handle excess nutrients a little longer than other plants can. Some are sensitive to it and immediately have issues. If your feeding all of your plants the same thing, and the same way, expect to see the same issues at some point.