@whitlow your plants are looking real nice! If you’re going to LST I would tie the main branch and get it bent over while they're still pliable and young. I like to loop a piece of cotton twine around the branch and use a binder clip to attach the twine to the side of the pot. I like using this method because you can adjust the tension as you go and you’re not relying on pre drilled holes for anchor points.
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As for defoliation I personally will wait until my plants are well into flower and only remove the larger leaves that are blocking my budsites from receiving light. However your plants are quite a bit bushier so you may want to do it a little sooner. Just remember the leaves are where the plant produces its energy so if you take too many you will stunt it. You just want to remove enough so there’s room in the plant for air to circulate.