There is no CXA3070 72v AFAIK. This thread is about mars conversions, too. So you're limited by the current provided from the drivers(around .7A) different voltage chips offer different wattages, efficiencies, and cost.
Outside of Mars conversions, the 36v and 72v cxb3590 offer different build options as well. I have a pair of 72v on an hlg185-1400, I'd need a 2.8A driver to get the same wattage out of the 36v version.
I'm not sure of a number for "safe voltage", I'd rather people use proper safety measures regardless of voltage. Don't have exposed wires, unplug before working on anything, never use both hands when something is live, don't stick a fork in the wall, etc.