Cannabis and digestive disorders

[Only1Sky]

@budelee, @MissUniverse - You two are very kind, but please don't go to anymore trouble or time. You've given me plenty to go on. I now know where the article was published. Also, in looking for it online, I did, like you said Budelee, run across a large volume of literature on the subject --- that's more than enough to keep me busy for quite a while. Thanks again all.

 

[MissUniverse]

@budelee, @MissUniverse - You two are very kind, but please don't go to anymore trouble or time. You've given me plenty to go on. I now know where the article was published. Also, in looking for it online, I did, like you said Budelee, run across a large volume of literature on the subject --- that's more than enough to keep me busy for quite a while. Thanks again all.

I still want to get you the continuing education, I have a off I just need to make sure it doesn't have,my name attached to it. Its legal to repost as its given out as coned you have to pay for if you want the credits and not just read it. Aka reading it is free

 

[MissUniverse]

@Only1Sky here's that con ed I was discussing, it is pretty plain English for people with some medical backgrounds, but I can help explain it.
https://www.netce.com/courseoverview.php?courseid=1238
If you don't want to click to read the course, here's the lazy mans link directly to the article in full
http://www.netce.com/coursecontent.php?courseid=1238&scrollTo=BEGIN



Here's the parts on ibs/bowel
Possible efficacy is suggested in fibromyalgia, post-traumatic stress disorder (PTSD), seizure disorders, and irritable bowel syndrome/Crohn's disease...

GASTROINTESTINAL DISORDERS/DYSFUNCTION
In one study of patients with chronic irritable bowel syndrome, inhaled cannabis for three months led to improvements in quality of life, disease activity, and weight gain
[169].
Observational study data in patients with Crohn's disease suggest that cannabis helps alleviate disease symptom severity and reduces the requirements for other medications and/or the need for surgery [170].

So there's some of the info,i can find with medical info. References 169 and 170 should be able to be found on pubmed, if you can't find them please let me know and I will get them linked here.

While chrons is different than I'd a lot of treatments are similar and it can be assumed that the same applies for ibs as chrons for our sake

Also make sure you read this study too. Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes”. I can privately send you the pdf for the article but this one I want the authors to be paid for their work because they put a lot in to it

 

[MissUniverse]

Here's the pubmed link for 169 "
Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study."
: https://www.ncbi.nlm.nih.gov/pubmed/22095142

abstract for those who dont want to click the link:

Abstract
BACKGROUND AND AIMS:
Inflammatory bowel disease (IBD) patients suffer from significant morbidity and diminished life quality. The plant cannabis is beneficial in various gastrointestinal diseases, stimulating appetite and causing weight gain. Our aims were to assess whether treatment with inhaled cannabis improves quality of life, disease activity and promotes weight gain in these patients.

METHODS:
Patients with long-standing IBD who were prescribed cannabis treatment were included. Two quality of life questionnaires and disease activity indexes were performed, and patient's body weight was measured before cannabis initiation and after 3 months' treatment.

RESULTS:
Thirteen patients were included. After 3 months' treatment, patients reported improvement in general health perception (p = 0.001), social functioning (p = 0.0002), ability to work (p = 0.0005), physical pain (p = 0.004) and depression (p = 0.007). A schematic scale of health perception showed an improved score from 4.1 ± 1.43 to 7 ± 1.42 (p = 0.0002). Patients had a weight gain of 4.3 ± 2 kg during treatment (range 2-8; p = 0.0002) and an average rise in BMI of 1.4 ± 0.61 (range 0.8-2.7; p = 0.002). The average Harvey-Bradshaw index was reduced from 11.36 ± 3.17 to 5.72 ± 2.68 (p = 0.001).

CONCLUSIONS:
Three months' treatment with inhaled cannabis improves quality of life measurements, disease activity index, and causes weight gain and rise in BMI in long-standing IBD patients

 

[Only1Sky]

@MissUniverse - you're awesome. Thanks so much for rounding up these references and links. I've clicked on everything, read all the abstracts, and downloaded what I had access to. Now I'll go off and read the full course content you sent. Many thanks.

 

[MissUniverse]

@MissUniverse - you're awesome. Thanks so much for rounding up these references and links. I've clicked on everything, read all the abstracts, and downloaded what I had access to. Now I'll go off and read the full course content you sent. Many thanks.

I have had a lot of help from people here regarding growing which is my weakness, the medical and pharmacological parts I understand very well and have tons of references for.
How are you making out with the reading? That netce course really is a great read but its super long but it is a great intro to all things cannabis to people who need to learn more. Its geared towards nurses who don't know much about cannabis. But every nurse I've ever talked to knows more about cannabis than the doctor they work with. Plus I have yet to see a nurse who is antimedical.

 

[MissUniverse]

@Only1Sky here's some more basic studies on PubMed where cannabis is discussed as a potential therapy in ibs, it may not have a lot of info on cannabis but they show just what modern day scientists and researchers really think if cannabis.

Potential causes and present pharmacotherapy of irritable bowel syndrome (IBS): an overview
Theodor Bokic, Martin Storr, and Rudolf Schicho
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541721/

[Efficacy, tolerability, and safety of cannabinoids in gastroenterology: A systematic review].
[Article in German]
https://www.ncbi.nlm.nih.gov/pubmed/26809974

Treating irritable bowel syndrome: overview, perspective and future therapies
Michael Camilleri
https://www.ncbi.nlm.nih.gov/pmc/articles/

Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
Russo EB1.
https://www.ncbi.nlm.nih.gov/pubmed/18404144

Clinical endocannabinoid deficiency (CECD) revisited: can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
Smith SC, Wagner MS.
https://www.ncbi.nlm.nih.gov/pubmed/24977967

Cannabis use amongst patients with inflammatory bowel disease.
Lal S1, Prasad N, Ryan M, Tangri S, Silverberg MS, Gordon A, Steinhart H.
https://www.ncbi.nlm.nih.gov/pubmed/21795981

 

[Only1Sky]

Whoa, @MissUniverse. Thanks, but you're drowning me in research abstracts. Here's the thing ... there's tons of studies (trials) showing that cannabis may provide symptomatic relief from a variety of gastrointestinal disorders. I find these of no personal interest. We're past wondering "IF it works", 'cause we know from personal experience that it does. In fact, one of the above articles states: "Cannabis has been used for centuries in the medicinal treatment of GI disorders."

What interests me is the HOW and WHY it works -- which can lead to a better understanding of what causes these disorders in the first place, as well as the potential for research that can lead to the prevention or permanent cure of same. To that end, the two articles on CECD were particularly relevant. Also, I liked the two overview articles, [HASHTAG]#1[/HASHTAG] "Potential Causes ..." and [HASHTAG]#3[/HASHTAG] "Treating ..."

Thanks again. I'm all set for now.

 

[MissUniverse]

Whoa, @MissUniverse. Thanks, but you're drowning me in research abstracts. Here's the thing ... there's tons of studies (trials) showing that cannabis may provide symptomatic relief from a variety of gastrointestinal disorders. I find these of no personal interest. We're past wondering "IF it works", 'cause we know from personal experience that it does. In fact, one of the above articles states: "Cannabis has been used for centuries in the medicinal treatment of GI disorders."

What interests me is the HOW and WHY it works -- which can lead to a better understanding of what causes these disorders in the first place, as well as the potential for research that can lead to the prevention or permanent cure of same. To that end, the two articles on CECD were particularly relevant. Also, I liked the two overview articles, [HASHTAG]#1[/HASHTAG] "Potential Causes ..." and [HASHTAG]#3[/HASHTAG] "Treating ..."

Thanks again. I'm all set for now.

When you need more,info let me,know. Just tag me. Reason I added those other studies is for future reference in case someone stumbles upon this and wants some more knowledge