There are several things that can contribute to droopy leaves. First of all it is water weight and gravity that is causing the droop. The leaves have more water weight than they can hold up. Several things can cause this to happen. You just watered/fertigated and the plant was thirsty taking water in faster than it can transpire it. Water leaves the plant through a process called transpiration. Little "holes" in the leaves called stomata "exhale" the water moisture out of the plant through the stomata. If the RH is too high or too low in relation to the ambient temperature the stomata will close to protect the plant from over transpiration or too high of heat. This backs the water up in the leaf and drooping is a result. It can also happen if a plant is in need of some nutrient that is not present in the root zone in a high enough PPM. The plant absorbs more water in an effort to get the nutrient and again a droop will result.
Out of balance nutrients not providing the building blocks for strong branches. A little added silica might help.
Then there may be a genetic propensity for drooping or the lights are not strong enough to encourage the leaves to stand up.
So as you can see it is not just one thing that can cause droopy leaves. I have never seen it stop a plant from making it to harvest.