Without some sort of fresh air and circulation you're just asking for trouble with fungus and mold. You could set up some CO², but you still need the exchange and flow. No chance of hooking a dryer hose up to a fan and discretely pulling some air in from somewhere (if you don't have a window like stoney suggested)?
if you get some CO2 you should be fine. My room is completely sealed, no air in, no air out, and I run CO2 and am growing just fine. My photo plants pull anywhere from 2-6 ounces a piece, depending on veg time.
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