I've been growing perpetually for 15 years by using one area for veg to supply two flower areas. I start a run every 2-3 weeks. Growing in small pots allows several strains to fit the areas.
Even though all areas are inside, intake air is from an outside source so my plants are always getting a dose of 'ambient' outside conditions, temps and all....I do see some changes due to outside influence but seems they adjust as long as parameters are close.
My systems are set up with inkbird and acinfinity fans and controls which make it just about a spectator sport. It's only summer that requires some hvac intervention.