What are you growing in, and exactly how hard is the water? Do you have a pH and hopefully a TDS or EC meter to check hardness? Mineral rich water will become an issue if it's bad enough,...cumulative amounts of CaCO3, usually not in available forms will start to drive pH up, interfere with nute uptake,... the spots are odd looking, not the usual color for Ca defc.,... the neem spraying, too muc too often can get the leaves touchy for reactions,...
If you're growing in soil, or peat based soilless, even coco, checking in-pot pH is critical,... As for ROor Di water, you can blend it with your dechlorinated tap water, but you'll need that EC/TDS meter to do it,..... BTW, how close is that light, and what's the T and RH% in there?
I'm growing in biobizz light mix. The water, although untested as I have no pH or EC checking equipment (but will make an investment soon), is 273 mg/l CaCO₃ according to my water board.
I don't think the neem is too much of an issue as I don't over do it and none of the other plants have an issue.
I have 3 x 600w cool tubes connected to a thermostat so if the temps do peak above 30C they will shut of and cool for a few minutes. The temps rang from 17C at min and 30C max. The lights are 15-19 inches from canopy and the RH IS 30%