That depends whether or not the strains were stabilized by taking them beyond an F1 o2 F2 generation. You won't often find a stable autoflower thats less than an F5 generation. True of photo period hybrids also. Even then, genetics rule and recessive genetic traits can pop out again at anytime.
We must be channeling pop22. I was just going to ask that very question. I always look at it like a box of Cracker Jacks with better prizes. I can see it being a pain in a large grow but for a small timer like me, I welcome surprises and even my wierdest grow delivered something good.