Yes, pH Perfect functioning is disrupted by excess salts (high ppm/EC), so you really want to use RO/DI water (near 0 ppm) and from there try to keep the salt additives to a minimum. For ex. if actually needed, I provide calcium-magnesium as foliar sprays, avoid adding these salts to the feed water. Microbial supplements should have no or trivial salts content, so you can use these all you want (but best to follow instructions or proven regimens such as you'll find on AFN).
Regarding microbial supplements, overall their need is much less with coco, hydro, etc. vs. living soil where nutrient availability is primarily if not solely ultimately due to microbial action. If in coco, hydro, etc., some other additives, such as using different P-K boosters during early vs. late bloom might be more critical.