I remove leaves for only two reasons. First, to maintain open air flow through the canopy so as to minimize the chance of mold. Second, to remove shaded lower leaves that don't get enough light to contribute to growth. At anything less than ~200 PPFD leaves use more resources than they produce, so in an indoor grow the plant is better off without them.
So, on your plant, as long as you have good air circulation through the canopy, you don't need to trim leaves. If all the leaves are gently moving in the air from your fan(s), you should be ok. If not, thin them out a bit. Trimming leaves that don't get enough light might help a bit, but is optional.
All my two cents worth of course.
If you're going to prune, a bottom prune of thin branches that are smaller than a pencil is the best option. Trim from the bottom up removing only branches that are thin, light isn't getting down there well enough as those branches aren't going to produce more than larf.
Bud sites don't photosynthesize, fan leaves do, and in your situation I would touch them. It looks like you're in the process or had went through some nutrient issues. Imagine if that problem got/gets worse and you're removing leaves, plant could die or have subpar growth because the fan leaves where the nutrients are stored have been removed.
Defoliation isn't really necessary unless there is concern for air circulation that could create micro climates that breed pest/mold/pathogens and it would done around first week of the stretch and then 10 days later to minimize stress along with the bottom prune.
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